8397
# of drugs
2320
# of cell lines
33
# tissues
739,964
# drug combinations
Total number of drug combinations per tissue. This bar plot will be updated according to the searching or selecting results.
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DrugA
Standardized name of row compound. |
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DrugB
Standardized name of column compound. |
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Cell_line
Cell line in which the drug combination is tested |
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CSS/RI
CSS is a drug combination sensitivity score that is derived using relative IC_50 and the area under the drug combination dose-response curves. |
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S
S synergy score is the % inhibition that is more than expected effect when the two drugs are additive at their relative IC_50s. |
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ZIP
ZIP synergy score is the % inhibition that is more than expected effect when the two drugs do not potentiate each other based on the Zero Interaction Potency model. |
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BLISS
Bliss synergy score is the % inhibition that is more than expected effect when the two drugs act in probabilistic independence based on the Bliss model. |
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LOEWE
Loewe synergy score is the % inhibition that is more than expected effect when the two drugs are actually the same based on the Loewe model. |
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HSA
HSA synergy score is the % inhibition that is more than expected as the highest single drug effect based on the Highest Single Agency model. |
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Block_ID
Block_ID is a numerical identifier referring to the screening results of one drug pair tested in all doses in one cancer cell line. |
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Histogram of CSS scores for the selected drug combination across all the cell lines
Histogram of CSS scores for the selected cell line across all the drug combinations
Barplots of CSS and S scores for all the drug combinations in the database, where the CSS and S scores for your selection are highlighted.
Dose response matrix for your selected drug combination.
Monotherapy dose-response curve for DrugA.
Monotherapy dose-response curve for DrugB.
Synergy landscape in the unit of % inhibition for your selected drug combination, based on ZIP model
Synergy landscape in the unit of % inhibition for your selected drug combination, based on BLISS model
Synergy landscape in the unit of % inhibition for your selected drug combination, based on LOEWE model
Synergy landscape in the unit of % inhibition for your selected drug combination, based on HSA model
Interpretation of the drug combination interaction network provided by STITCH database.
STITCH VIEW
Network Features:
1. Zoom in/out
2. Click on specific node to see the connection.
3. Saving/Copying the network as an image by right click.
Chemical structures for the selected drug combinations by PubChem database. Click the CID for more information.
PUBCHEM VIEW
Predicted drug target interactions for the selected drug combination by ChEMBL database. Click the ChEMBLID for more information.